Author Guidelines

Cover Letter
Cover letters must include the following:

  1. A title for the article limited to 125 characters including spaces
  2. The desired article format (article type) of the manuscript being submitted
  3. An indication for the number of figures, tables, and supplementary data files associated with the manuscript
  4. A disclosure of similar manuscripts that may be under review, in press or published elsewhere (even if in a different language)
  5. Potential author conflicts of interest (refer to the Hypothesis Editorial Policies for detailed information)
  6. The name, affiliation, address, telephone number and e-mail address of the corresponding author, who will be primarily responsible for communication with the journal pre- and post-publication
  7. The names of up to 5 suitable independent reviewers for the manuscript, and up to 5 individuals who should not be asked to review it due to professional conflicts of interest (along with supporting explanations)

Title page
Title pages must include the full names of all authors as well as the designated corresponding affiliations. Affiliations must contain the following information: department, institution, city, state / province / region, postal code, country, e-mail address. The corresponding author(s) should be clearly indicated. Additional footnotes may be used to provide the present address of an author, or a statement that multiple authors contributed equally to the work. Titles for papers in Hypothesis are not to exceed 125 characters with spaces.

Abstracts should provide the reader with a complete glimpse into the most important aspects of the paper. A good abstract will usually start by providing background information into the primary question that is addressed by the paper. The main section of the abstract should then include reference to the most striking and strongest ideas, followed by the article hypothesis/conclusion. We regret that we cannot accept abstracts exceeding 175 words. Citations are not permitted in abstracts. The use of abbreviations should be minimized. Abstracts should be one, single paragraph.

Body text
Organization of the text by the judicious use of headings and subheading is encouraged. Text should be Times New Roman or Arial type-face, 10-12 points in size, and double-spaced. Pages must be numbered. Footnotes are not accepted. Non-standard abbreviations must be defined when first used in the text. In general, however, use of abbreviations should be minimized. Gene symbols must be italicized. Protein products should not be italicized. New gene sequences, protein sequences, structures, or microarray data must be accompanied by database accession numbers. Standard International (SI) Units must be used. Except for “%” and “°C”, one space must be placed between a number and the corresponding unit.

Acknowledge all individuals who do no meet the criteria for authorship, but nevertheless contributed to the work via: (1) study conception or design; (2) collection of data; (3) analysis or interpretation of data; (4) drafting or revision of the manuscript; (5) provision of technical services; (6) provision of materials; (7) general supervision of the research group. Individuals appearing in the acknowledgments must have provided written permission.

Acknowledge source(s) of funding for: (1) the study; (2) each author; (3) manuscript preparation (if any). Describe the role of funding sources (if any) in: (1) study design; (2) collection/analysis/interpretation of data; (3) manuscript preparation; (4) decision to submit for publication.

About the Author(s)
Authors at Hypothesis are requested to write a 100 word description of the authors that provides more information to the reader than what is already provided by listing the author affiliations. 100 words should not be exceeded even when describing several authors, although special consideration will be considered for manuscripts containing a large number of authors.

References should be formatted according to the standard “Vancouver” referencing system, and should include the DOI number (click here for examples). The Vancouver system is available in most referencing software, including EndNote. Please note that Hypothesis Journal uses the full format for DOI numbers in references (see the reference list in this article). Authors are encouraged to download, install, and use the following EndNote reference style file: Vancouver.

For publications with many authors, list the first 6 author names followed by “et al.” Citations should be numbered consecutively (in round parentheses) in the order in which they are cited in the text, followed by tables and figure legends. Citations should not appear in abstracts, titles, or headings. Titles of journals in the reference list should be abbreviated according to the style used in Index Medicus; refer to the list of journals indexed for MEDLINE, published annually by the U.S. National Library of Medicine.

Manuscripts that are accepted but not yet published should be designated as “in press”; only items that are published or in press should be cited in the reference list.

Information from manuscripts that are in preparation (or submitted but not accepted) should be cited as “unpublished data” in parentheses in the text, and should not be included in the reference list.

“Personal communications” should be cited in parentheses in the text, giving the name of the cited individual and the date of communication, and should not be included in the reference list. Authors should avoid citing a personal communication unless it provides vital information that is unavailable from any public source. Permission to cite personal communications and others’ unpublished data must be obtained from the source.

References to Wikipedia or other information websites cannot be used to support scientific claims, with the exception of government documents that are not available in published format in a peer-reviewed journal. Similarly, references to possible predatory journals as assessed by Jeffrey Beall, librarian at Auraria Library, University of Colorado Denver, are not accepted at Hypothesis. The list of journals can be found here:

Tables & Table Legends
Tables can be created using Microsoft Word table function or equivalent. Colour or shading should not be used. Number tables consecutively in the order of their first citation in the text. For each table, authors must provide a table number (i.e. Table 1), a short title, and a concise legend.

Figure Legends
Figures must be numbered consecutively in the order of their first citation in the text. For each figure legend, please provide the figure number (i.e. Figure 1), a short title, and a description that allows the figure to be understood without reference to the main text. Figure legends should not exceed 300 words.

Colour mode for figures should be CMYK or grayscale. Resolution of figures should be a minimum of 300 dpi at their final printed size. Graph lines, error bars, and outlines must be at least ½ point in weight at their final printed size. Text appearing in figures should be Arial font, between 8 and 12 points. If a figure has been previously published, the original source must be acknowledged, and authors are responsible for obtaining written permission from the copyright owner for reproduction.

Description of Supplemental Data
For each supplemental data file, provide (1) the file name and format, (2) the title; (3) a concise description.

Submission of Revised Manuscripts
Unless otherwise indicated, revised manuscripts must be resubmitted to Hypothesis within 3 months of receiving the editorial decision. Revised manuscripts must be accompanied by detailed point-by-point responses to the comments of the reviewers and/or editors and include reference to the precise page numbers. Revised manuscripts must be uploaded to the Hypothesis website in the Editor Decision section.

Submission of Accepted Manuscripts
Accepted manuscript text and tables must be provided in a word file (DOC or RTF). Figures must be provided in TIFF format at a resolution of 300 dpi minimum (in Photoshop, choose LZW compression). Other image file formats and PDFs can be opened in Photoshop and saved as a TIFF. PowerPoint files can be converted to a PDF and then handled as above. Accepted manuscripts must be uploaded to the Hypothesis website in the Editor Decision section.

Authors of accepted manuscripts are invited to submit a small graphic image (JPG or GIF) to be posted alongside the link to their article on the Hypothesis website. If authors do not provide an acceptable image, one will be selected or created by the Editorial Office (for more information contact