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The ‘Mighty Mouse’ Model in experimental cardiac transplantation
Abstract Tissue rejection remains a major problem in organ transplantation. The use of experimental animal models continues to enhance our understanding of the rejection process and offers strategies for its prevention. The popular mouse model of heterotopic cardiac transplantation has been used for over three decades to help investigators understand the pathogenesis of graft rejection ...
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Information Retrieval: Literature Searching in Today’s Information Landscape
Abstract In this era of exponential growth in the amount of scientific information, the ability to perform efficient literature searches is a key skill for students and researchers. This review covers essential aspects of literature searching, including devising a search strategy and selecting sources to search. Examples will be drawn from the field of biomedical ...
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The Evolution of Breast Tumor Therapeutics – A review
Abstract Survival rate among breast cancer patients has significantly increased over the past 20 years due to improved therapeutic regimens and better screening strategies. Though the mainstay of tumor treatment has been surgical removal of the tumor mass, it is the improvement in adjuvant chemotherapeutic armamentarium that has contributed most to a decline in the ...
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Fun with Microarrays Part II: Data Analysis
Abstract Microarray experiments are an important method for the high-throughput investigation of biological phenomenon. A wide variety of techniques and algorithms exist for analyzing and extracting information from microarrays. While the mathematical details of each algorithm are beyond the ken of most biologists, the basic steps and rationales underlying microarray data analysis need not be. ...
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The Scientific Workforce Policy Debate: Do We Produce too Many Biomedical Trainees?
Abstract The number of trainees that the biomedical research enterprise produces currently far exceeds the number of academic PI positions available. Although calls for increased funding of research are routine, relatively few in the scientific community have asked the question, “Are we producing too many trainees?” Here, I review current thinking on this issue in ...
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Fun with Microarrays Part III: Integration and the End of Microarrays as We Know Them
Abstract Microarray experiments are an important method for the high-throughput investigation of biological phenomenon. A wide variety of techniques and algorithms exist for analyzing and extracting information from microarrays. This is the last of a series of reviews outlining the technological, computational, and experimental aspects of microarray experiments. This part focuses on cutting-edge applications of ...