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Periodontal disease and systemic amyloidosis: From inflammation to amyloidosis — a troubling connection
Abstract It has become increasingly clear in recent years that periodontal disease can cause dramatic increases in the levels of markers of systemic inflammation and can also result in reductions in the levels of these markers. It is also known that amyloid fibril deposits derived from circulating acute-phase reactant serum amyloid A (SAA) lead to ...
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The role of microRNAs in the formation of cancer stem cells: Future directions for miRNAs
Abstract The scientific investigation of microRNAs (miRNAs) and cancer stem cells is of considerable interest. Cancer stem cells are a small subpopulation of cells identified in a variety of tumors and capable of self-renewal, differentiation, chemoresistance and tumorigenesis. MiRNAs are small (18-24 nucleotide) RNAs that regulate expression of genes at the post-transcriptional level. Recently, many ...